PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2539976-0	1989	Interleukin-1 alpha exerts glucose-dependent stimulatory and inhibitory effects on islet cell phosphoinositide hydrolysis and insulin secretion.	Glucose	27-34	interleukin 1 alpha	Homo sapiens	0-19	
2539976-5	1989	1) In islets labeled for 2 h with [3H]inositol in the presence of 2.75 mM glucose, subsequent perifusion with 5.0 nM IL-1 increased insulin output, [3H]inositol efflux, and [3H]inositol phosphate accumulation in the simultaneous presence of 7 mM, but not 2.75 mM, glucose.	Glucose	264-271	interleukin 1 alpha	Homo sapiens	117-121	
2539976-6	1989	2) Mannoheptulose, a competitive inhibitor of islet glucokinase, blocked the stimulatory effects of IL-1 noted in the presence of 7 mM glucose.	Glucose	135-142	interleukin 1 alpha	Homo sapiens	100-104	
2539976-12	1989	6) These inhibitory effects of IL-1 were abolished if mannoheptulose was included during the 2-h incubation with 7 mM glucose plus 5.0 nM <protein-id="3605">IL-1.	Glucose	118-125	interleukin 1 alpha	Homo sapiens	31-35	
2539976-13	1989	7</protein-id>) The diacylglycerol kinase inhibitor 1-monooleoylglycerol (100 microM) significantly restored insulin output after IL-1 exposure (with 7 mM glucose).	Glucose	155-162	interleukin 1 alpha	Homo sapiens	130-134	
2539976-14	1989	8) Similar to the results obtained with 7 mM glucose plus IL-1, incubation of islets with 8-10 mM glucose alone produced dose-dependent impairments of [3H]inositol efflux patterns and inositol phosphate accumulation.	Glucose	98-105	interleukin 1 alpha	Homo sapiens	58-62	
2539976-16	1989	These results demonstrate that IL-1 has glucose-dependent stimulatory and inhibitory effects on beta-cell function.	Glucose	40-47	interleukin 1 alpha	Homo sapiens	31-35