PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2539864-0 1989 Plasma membrane associated phospholipase C from human platelets: synergistic stimulation of phosphatidylinositol 4,5-bisphosphate hydrolysis by thrombin and guanosine 5"-O-(3-thiotriphosphate). Phosphatidylinositol 4,5-Diphosphate 92-129 coagulation factor II, thrombin Homo sapiens 144-152 2539864-6 1989 At submicromolar calcium concentration, hydrolysis of exogenous phosphatidylinositol 4,5-bisphosphate (PIP2) by platelet membrane associated PLC was also markedly enhanced by GTP gamma S (100 microM) or GTP gamma S (1 microM) plus thrombin (1 unit/mL). Phosphatidylinositol 4,5-Diphosphate 64-101 coagulation factor II, thrombin Homo sapiens 231-239 2539864-6 1989 At submicromolar calcium concentration, hydrolysis of exogenous phosphatidylinositol 4,5-bisphosphate (PIP2) by platelet membrane associated PLC was also markedly enhanced by GTP gamma S (100 microM) or GTP gamma S (1 microM) plus thrombin (1 unit/mL). Phosphatidylinositol 4,5-Diphosphate 103-107 coagulation factor II, thrombin Homo sapiens 231-239 2539864-9 1989 Thrombin-induced hydrolysis of PIP2 was inhibited by treatment of the membranes with pertussis toxin or pretreatment of intact platelets with 12-O-tetradecanoyl-13-acetate (TPA) prior to preparation of membranes. Phosphatidylinositol 4,5-Diphosphate 31-35 coagulation factor II, thrombin Homo sapiens 0-8