PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2539818-0	1989	Effects of alpha-1-acid glycoprotein administration on propranolol binding and beta blockade in rats.	Propranolol	55-66	orosomucoid 1	Rattus norvegicus	11-36	
2539818-1	1989	Alpha-1-acid glycoprotein (AAG), 750 mg/kg, was administered to rats to determine its effect on propranolol binding and beta blockade.	Propranolol	96-107	orosomucoid 1	Rattus norvegicus	0-25	
2539818-4	1989	AAG treatment significantly increased the heart rate response to isoproterenol, compared to albumin (95.4 +/- 19.6 vs 28.3 +/- 16.7% of baseline value, measured 45 min after propranolol, P less than 0.001).	Propranolol	174-185	orosomucoid 1	Rattus norvegicus	0-3	
2539818-5	1989	AAG-treated rats had greater [3H]propranolol binding in serum (93.0 +/- 3.2 vs 76.7 +/- 3.0%, P less than 0.01) and a lower calculated unbound [3H]propranolol concentration in serum (2.7 +/- 1.3 vs 7.4 +/- 3.1 X 10(6) dpm/ml, P less than 0.001) than albumin-treated rats.	Propranolol	33-44	orosomucoid 1	Rattus norvegicus	0-3	
2539818-5	1989	AAG-treated rats had greater [3H]propranolol binding in serum (93.0 +/- 3.2 vs 76.7 +/- 3.0%, P less than 0.01) and a lower calculated unbound [3H]propranolol concentration in serum (2.7 +/- 1.3 vs 7.4 +/- 3.1 X 10(6) dpm/ml, P less than 0.001) than albumin-treated rats.	Propranolol	147-158	orosomucoid 1	Rattus norvegicus	0-3	
2539818-6	1989	These data demonstrate that AAG can alter propranolol pharmacokinetics and pharmacodynamics even when administered after the propranolol effect is evident.	Propranolol	42-53	orosomucoid 1	Rattus norvegicus	28-31	
2539818-6	1989	These data demonstrate that AAG can alter propranolol pharmacokinetics and pharmacodynamics even when administered after the propranolol effect is evident.	Propranolol	125-136	orosomucoid 1	Rattus norvegicus	28-31	
2539818-7	1989	Because the reported affinity of propranolol for cardiac beta receptors is 10,000 times greater than its affinity for AAG, these data suggest that AAG acted by altering propranolol disposition rather than by directly competing with beta receptors for drug.	Propranolol	33-44	orosomucoid 1	Rattus norvegicus	147-150	
2539818-7	1989	Because the reported affinity of propranolol for cardiac beta receptors is 10,000 times greater than its affinity for AAG, these data suggest that AAG acted by altering propranolol disposition rather than by directly competing with beta receptors for drug.	Propranolol	169-180	orosomucoid 1	Rattus norvegicus	147-150