PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25342886-0 2014 Indole and synthetic derivative activate chaperone expression to reduce polyQ aggregation in SCA17 neuronal cell and slice culture models. polyglutamine 72-77 ataxin 7 Homo sapiens 93-98 25342886-1 2014 In spinocerebellar ataxia type 17 (SCA17), the expansion of a translated CAG repeat in the TATA box binding protein (TBP) gene results in a long polyglutamine (polyQ) tract in the TBP protein, leading to intracellular accumulation of aggregated TBP and cell death. polyglutamine 145-158 ataxin 7 Homo sapiens 35-40 25342886-1 2014 In spinocerebellar ataxia type 17 (SCA17), the expansion of a translated CAG repeat in the TATA box binding protein (TBP) gene results in a long polyglutamine (polyQ) tract in the TBP protein, leading to intracellular accumulation of aggregated TBP and cell death. polyglutamine 160-165 ataxin 7 Homo sapiens 35-40 25342886-6 2014 Our results demonstrate how indole and derivative NC001-8 reduce polyQ aggregation to support their therapeutic potentials in SCA17 treatment. polyglutamine 65-70 ataxin 7 Homo sapiens 126-131