PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25251877-0 2014 Human regulatory T cells lack the cyclophosphamide-extruding transporter ABCB1 and are more susceptible to cyclophosphamide-induced apoptosis. Cyclophosphamide 34-50 ATP binding cassette subfamily B member 1 Homo sapiens 73-78 25251877-2 2014 Susceptibility of CD4(+) regulatory T (Treg) cells to the ABCB1-substrate cyclophosphamide (CPA) has been reported. Cyclophosphamide 74-90 ATP binding cassette subfamily B member 1 Homo sapiens 58-63 25251877-2 2014 Susceptibility of CD4(+) regulatory T (Treg) cells to the ABCB1-substrate cyclophosphamide (CPA) has been reported. Cyclophosphamide 92-95 ATP binding cassette subfamily B member 1 Homo sapiens 58-63 25251877-6 2014 In vitro, the ABCB1-substrate CPA was cytotoxic for Treg cells at a 100-fold lower dose than for nonregulatory counterparts, and, inversely, verapamil, an inhibitor of ABC transporters, increased CPA-toxicity in nonregulatory CD4(+) T cells but not Treg cells. Cyclophosphamide 30-33 ATP binding cassette subfamily B member 1 Homo sapiens 14-19 25251877-6 2014 In vitro, the ABCB1-substrate CPA was cytotoxic for Treg cells at a 100-fold lower dose than for nonregulatory counterparts, and, inversely, verapamil, an inhibitor of ABC transporters, increased CPA-toxicity in nonregulatory CD4(+) T cells but not Treg cells. Cyclophosphamide 196-199 ATP binding cassette subfamily B member 1 Homo sapiens 14-19