PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25101238-0 2014 Role of GLUT1 in regulation of reactive oxygen species. Reactive Oxygen Species 31-54 solute carrier family 2 member 1 Homo sapiens 8-13 25101238-2 2014 We hypothesized that conditions that would decrease GLUT1-mediated transport would cause increased reactive oxygen species (ROS) levels in L6 myoblasts, while conditions that would increase GLUT1-mediated transport would result in decreased ROS levels. Reactive Oxygen Species 99-122 solute carrier family 2 member 1 Homo sapiens 52-57 25101238-2 2014 We hypothesized that conditions that would decrease GLUT1-mediated transport would cause increased reactive oxygen species (ROS) levels in L6 myoblasts, while conditions that would increase GLUT1-mediated transport would result in decreased ROS levels. Reactive Oxygen Species 124-127 solute carrier family 2 member 1 Homo sapiens 52-57 25101238-3 2014 We found that the GLUT1 inhibitors fasentin and phloretin increased the ROS levels induced by antimycin A and the superoxide generator pyrogallol. Reactive Oxygen Species 72-75 solute carrier family 2 member 1 Homo sapiens 18-23 25101238-6 2014 Mutation of an ATM target site on GLUT1 (GLUT1-S490A) increased ROS levels and prevented the ROS-lowering effect of the ATM activator doxorubicin. Reactive Oxygen Species 64-67 solute carrier family 2 member 1 Homo sapiens 34-39 25101238-6 2014 Mutation of an ATM target site on GLUT1 (GLUT1-S490A) increased ROS levels and prevented the ROS-lowering effect of the ATM activator doxorubicin. Reactive Oxygen Species 64-67 solute carrier family 2 member 1 Homo sapiens 41-46 25101238-6 2014 Mutation of an ATM target site on GLUT1 (GLUT1-S490A) increased ROS levels and prevented the ROS-lowering effect of the ATM activator doxorubicin. Reactive Oxygen Species 93-96 solute carrier family 2 member 1 Homo sapiens 34-39 25101238-6 2014 Mutation of an ATM target site on GLUT1 (GLUT1-S490A) increased ROS levels and prevented the ROS-lowering effect of the ATM activator doxorubicin. Reactive Oxygen Species 93-96 solute carrier family 2 member 1 Homo sapiens 41-46 25101238-7 2014 In contrast, expression of GLUT1-S490D lowered ROS levels during challenge with pyrogallol, prevented an increase in ROS when ATM was inhibited, and prevented the pyrogallol-induced decrease in insulin signaling and insulin-stimulated glucose transport. Reactive Oxygen Species 47-50 solute carrier family 2 member 1 Homo sapiens 27-32 25101238-7 2014 In contrast, expression of GLUT1-S490D lowered ROS levels during challenge with pyrogallol, prevented an increase in ROS when ATM was inhibited, and prevented the pyrogallol-induced decrease in insulin signaling and insulin-stimulated glucose transport. Reactive Oxygen Species 117-120 solute carrier family 2 member 1 Homo sapiens 27-32 25101238-8 2014 Taken together, the data suggest that GLUT1 plays a role in regulation of ROS and could contribute to maintenance of insulin action in the presence of ROS. Reactive Oxygen Species 74-77 solute carrier family 2 member 1 Homo sapiens 38-43 25101238-8 2014 Taken together, the data suggest that GLUT1 plays a role in regulation of ROS and could contribute to maintenance of insulin action in the presence of ROS. Reactive Oxygen Species 151-154 solute carrier family 2 member 1 Homo sapiens 38-43