PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25032863-0	2014	Deacetylation of the tumor suppressor protein PML regulates hydrogen peroxide-induced cell death.	Hydrogen Peroxide	60-77	PML nuclear body scaffold	Homo sapiens	46-49	
25032863-3	2014	Here we demonstrate that acetylation of lysine 487 (K487) and SUMO1 conjugation of K490 at PML protein are mutually exclusive.	Lysine	40-46	PML nuclear body scaffold	Homo sapiens	91-94	
25032863-4	2014	We found that hydrogen peroxide (H2O2) promotes PML deacetylation and identified SIRT1 and SIRT5 as PML deacetylases.	Hydrogen Peroxide	14-31	PML nuclear body scaffold	Homo sapiens	48-51	
25032863-4	2014	We found that hydrogen peroxide (H2O2) promotes PML deacetylation and identified SIRT1 and SIRT5 as PML deacetylases.	Hydrogen Peroxide	14-31	sirtuin 1	Homo sapiens	81-86	
25032863-4	2014	We found that hydrogen peroxide (H2O2) promotes PML deacetylation and identified SIRT1 and SIRT5 as PML deacetylases.	Hydrogen Peroxide	14-31	sirtuin 5	Homo sapiens	91-96	
25032863-4	2014	We found that hydrogen peroxide (H2O2) promotes PML deacetylation and identified SIRT1 and SIRT5 as PML deacetylases.	Hydrogen Peroxide	14-31	PML nuclear body scaffold	Homo sapiens	100-103	
25032863-4	2014	We found that hydrogen peroxide (H2O2) promotes PML deacetylation and identified SIRT1 and SIRT5 as PML deacetylases.	Hydrogen Peroxide	33-37	PML nuclear body scaffold	Homo sapiens	48-51	
25032863-5	2014	Both SIRT1 and SIRT5 are required for H2O2-mediated deacetylation of PML and accumulation of nuclear PML protein in HeLa cells.	Hydrogen Peroxide	38-42	sirtuin 1	Homo sapiens	5-10	
25032863-5	2014	Both SIRT1 and SIRT5 are required for H2O2-mediated deacetylation of PML and accumulation of nuclear PML protein in HeLa cells.	Hydrogen Peroxide	38-42	sirtuin 5	Homo sapiens	15-20	
25032863-5	2014	Both SIRT1 and SIRT5 are required for H2O2-mediated deacetylation of PML and accumulation of nuclear PML protein in HeLa cells.	Hydrogen Peroxide	38-42	PML nuclear body scaffold	Homo sapiens	69-72	
25032863-5	2014	Both SIRT1 and SIRT5 are required for H2O2-mediated deacetylation of PML and accumulation of nuclear PML protein in HeLa cells.	Hydrogen Peroxide	38-42	PML nuclear body scaffold	Homo sapiens	101-104	
25032863-6	2014	Knockdown of SIRT1 reduces the number of H2O2-induced PML-nuclear bodies (NBs) and increases the survival of HeLa cells.	Hydrogen Peroxide	41-45	sirtuin 1	Homo sapiens	13-18	
25032863-6	2014	Knockdown of SIRT1 reduces the number of H2O2-induced PML-nuclear bodies (NBs) and increases the survival of HeLa cells.	Hydrogen Peroxide	41-45	PML nuclear body scaffold	Homo sapiens	54-57	
25032863-7	2014	Ectopic expression of wild-type PML but not the K487R mutant rescues H2O2-induced cell death in SIRT1 knockdown cells.	Hydrogen Peroxide	69-73	PML nuclear body scaffold	Homo sapiens	32-35	
25032863-7	2014	Ectopic expression of wild-type PML but not the K487R mutant rescues H2O2-induced cell death in SIRT1 knockdown cells.	Hydrogen Peroxide	69-73	sirtuin 1	Homo sapiens	96-101	
25032863-8	2014	Furthermore, ectopic expression of wild-type SIRT5 but not a catalytic defective mutant can also restore H2O2-induced cell death in SIRT1 knockdown cells.	Hydrogen Peroxide	105-109	sirtuin 5	Homo sapiens	45-50	
25032863-8	2014	Furthermore, ectopic expression of wild-type SIRT5 but not a catalytic defective mutant can also restore H2O2-induced cell death in SIRT1 knockdown cells.	Hydrogen Peroxide	105-109	sirtuin 1	Homo sapiens	132-137