PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24959968-0 2014 Interactions that influence the binding of synthetic heparan sulfate based disaccharides to fibroblast growth factor-2. Disaccharides 75-88 fibroblast growth factor 2 Homo sapiens 92-118 24959968-4 2014 Herein, we evaluated the affinities of the same sugars against FGF2 and determined the crystal structures of FGF2 in complex with three disaccharides carrying N-sulfonated glucosamine and 2-O-sulfonated iduronic acid as basic backbones. Disaccharides 136-149 fibroblast growth factor 2 Homo sapiens 109-113 24959968-7 2014 These findings suggest that the water-mediated interactions and the intermolecular interactions influence the binding affinity of different disaccharides with FGF2, correlating with their respective dissociation constants in solution. Disaccharides 140-153 fibroblast growth factor 2 Homo sapiens 159-163