PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24723845-7 2014 Nicotinamide has been proposed as a suitable PARP-1 inhibitor. Niacinamide 0-12 poly (ADP-ribose) polymerase 1 Rattus norvegicus 45-51 24723845-11 2014 Nicotinamide rapidly distributes into the brain following systemic administration, reaching steady state concentrations sufficient to inhibit PARP-1 activity for several hours, preventing several of the long-term consequences of perinatal asphyxia, supporting the idea that nicotinamide constitutes a lead for exploring compounds with similar or better pharmacological profiles. Niacinamide 0-12 poly (ADP-ribose) polymerase 1 Rattus norvegicus 142-148 24723845-11 2014 Nicotinamide rapidly distributes into the brain following systemic administration, reaching steady state concentrations sufficient to inhibit PARP-1 activity for several hours, preventing several of the long-term consequences of perinatal asphyxia, supporting the idea that nicotinamide constitutes a lead for exploring compounds with similar or better pharmacological profiles. Niacinamide 274-286 poly (ADP-ribose) polymerase 1 Rattus norvegicus 142-148