PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24721791-5 2014 Moreover, repression of the IRF4 target gene MYC in bortezomib-resistant cells by gene knockdown or treatment with CPI203, a BET (bromodomain and extra terminal) bromodomain inhibitor, synergistically induced cell death when combined with lenalidomide. Lenalidomide 239-251 myelocytomatosis oncogene Mus musculus 45-48 24721791-7 2014 Together, these results suggest that exacerbated IRF4/MYC signaling is associated to bortezomib resistance in MCL in vivo and warrant clinical evaluation of lenalidomide plus BET inhibitor combination in MCL cases refractory to proteasome inhibition. Lenalidomide 157-169 myelocytomatosis oncogene Mus musculus 54-57