PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24657625-11 2014 RESULTS: In macrophages and monocytes, increasing concentrations of lactate reduced TLR4-mediated induction of Il1B, Nlrp3, and Casp1; activation of NF-kappaB; release of IL1beta; and cleavage of CASP1. Lactic Acid 68-75 interleukin 1 beta Mus musculus 111-115 24657625-11 2014 RESULTS: In macrophages and monocytes, increasing concentrations of lactate reduced TLR4-mediated induction of Il1B, Nlrp3, and Casp1; activation of NF-kappaB; release of IL1beta; and cleavage of CASP1. Lactic Acid 68-75 interleukin 1 beta Mus musculus 171-178 24657625-15 2014 CONCLUSIONS: Lactate negatively regulates TLR induction of the NLRP3 inflammasome and production of IL1beta, via ARRB2 and GPR81. Lactic Acid 13-20 interleukin 1 beta Mus musculus 100-107