PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24422572-6 2014 The fact that the accumulation of metabolic substrates such as monosodium urate, ceramide, cholesterol, and glucose can trigger the NLRP3 inflammasome connects metabolic stress to IL-1beta-mediated inflammation and provides a rationale for therapeutically targeting IL-1 in prevalent diseases such as gout, diabetes mellitus, and coronary artery disease. Glucose 108-115 NLR family pyrin domain containing 3 Homo sapiens 132-137