PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24333670-2	2014	The detailed mechanisms of caffeine in tumor suppression via tumor suppressor protein p53 remain unclear.	Caffeine	27-35	tumor protein p53	Homo sapiens	86-89	
24333670-4	2014	In this study, we investigated how caffeine modulated cell cycle arrest and apoptosis via the expression of various alternatively spliced p53 isoforms.	Caffeine	35-43	tumor protein p53	Homo sapiens	138-141	
24333670-5	2014	Caffeine reduced p53alpha expression and induced the expression of p53beta, which contains an alternatively spliced p53 C-terminus.	Caffeine	0-8	tumor protein p53	Homo sapiens	17-20	
24333670-5	2014	Caffeine reduced p53alpha expression and induced the expression of p53beta, which contains an alternatively spliced p53 C-terminus.	Caffeine	0-8	tumor protein p53	Homo sapiens	67-70	
24333670-7	2014	Serine/arginine-rich splicing factor 3 was a promising candidate for the serine/arginine-rich splicing factors responsible for the alternative splicing of p53 in response to caffeine treatment.	Caffeine	174-182	tumor protein p53	Homo sapiens	155-158	
24333670-8	2014	In addition to p53-dependent functions, multiple target genes of serine/arginine-rich splicing factor 3 suggest that caffeine can regulate epithelial-mesenchymal-transition and hypoxic conditions to inhibit the survival of tumor cells.	Caffeine	117-125	tumor protein p53	Homo sapiens	15-18