PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24100030-4 2013 Specifically, we show that TRAIL treatment activates the tyrosine kinase Src, which subsequently phosphorylates caspase-8 at tyrosine 380, leading to the inhibition of caspase-8 activation. Tyrosine 57-65 caspase 8 Homo sapiens 112-121 24100030-4 2013 Specifically, we show that TRAIL treatment activates the tyrosine kinase Src, which subsequently phosphorylates caspase-8 at tyrosine 380, leading to the inhibition of caspase-8 activation. Tyrosine 57-65 caspase 8 Homo sapiens 168-177 24100030-5 2013 We also show that upon TRAIL treatment, Src, caspase-8, and PP2A/C (a catalytic subunit of the PP2A phosphatase) are redistributed into lipid rafts, a microdomain of the plasma membrane enriched with cholesterol, where PP2A dephosphorylates Src at tyrosine 418 and in turn inhibits caspase-8 phosphorylation. Tyrosine 248-256 caspase 8 Homo sapiens 45-54