PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23946688-0	2013	Mutant p53-Notch1 Signaling Axis Is Involved in Curcumin-Induced Apoptosis of Breast Cancer Cells.	Curcumin	48-56	tumor protein p53	Homo sapiens	7-10	
23946688-3	2013	The present study aimed to determine whether the mutant p53 can be a potent transcriptional activator of the Notch1 in MDA-MB-231 cells, and explore the role of this mutant p53-Notch1 axis in curcumin-induced apoptosis.	Curcumin	192-200	tumor protein p53	Homo sapiens	56-59	
23946688-3	2013	The present study aimed to determine whether the mutant p53 can be a potent transcriptional activator of the Notch1 in MDA-MB-231 cells, and explore the role of this mutant p53-Notch1 axis in curcumin-induced apoptosis.	Curcumin	192-200	tumor protein p53	Homo sapiens	173-176	
23946688-6	2013	We confirmed the suppressive effect of curcumin on Notch1 transcription by performing a Notch1 promoter-driven reporter assay and identified a putative p53-binding site in the Notch1 promoter by EMSA and chromatin immunoprecipitation analysis.	Curcumin	39-47	tumor protein p53	Homo sapiens	152-155	
23946688-8	2013	Moreover, curcumin-induced apoptosis was further enhanced by the knockdown of Notch1 or mutant p53, but it was decreased by the overexpression of active Notch1.	Curcumin	10-18	tumor protein p53	Homo sapiens	95-98	
23946688-9	2013	Taken together, our results demonstrate, for the first time, that Notch1 is a transcriptional target of mutant p53 in breast cancer cells and suggest that the targeting of mutant p53 and/or Notch1 may be combined with a chemotherapeutic strategy to improve the response of breast cancer cells to curcumin.	Curcumin	296-304	tumor protein p53	Homo sapiens	111-114	
23946688-9	2013	Taken together, our results demonstrate, for the first time, that Notch1 is a transcriptional target of mutant p53 in breast cancer cells and suggest that the targeting of mutant p53 and/or Notch1 may be combined with a chemotherapeutic strategy to improve the response of breast cancer cells to curcumin.	Curcumin	296-304	tumor protein p53	Homo sapiens	179-182