PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23874021-7 2013 Canakinumab is a human monoclonal antibody that selectively neutralizes IL-1beta, a pro-inflammatory cytokine that plays multiple roles in the atherothrombotic process and that undergoes activation by the NLRP3 inflammasome, a process promoted by cholesterol crystals that in turn leads directly to increased production of IL-1 and IL-6. Cholesterol 247-258 NLR family pyrin domain containing 3 Homo sapiens 205-210