PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23743668-0 2013 Genetic polymorphisms in ABCB1 influence the pharmacodynamics of tacrolimus. Tacrolimus 65-75 ATP binding cassette subfamily B member 1 Homo sapiens 25-30 23743668-7 2013 In addition, the ABCB1 genotype of 36 tacrolimus-treated renal transplant patients was related to ABCB1 activity and tacrolimus efficacy. Tacrolimus 38-48 ATP binding cassette subfamily B member 1 Homo sapiens 17-22 23743668-7 2013 In addition, the ABCB1 genotype of 36 tacrolimus-treated renal transplant patients was related to ABCB1 activity and tacrolimus efficacy. Tacrolimus 38-48 ATP binding cassette subfamily B member 1 Homo sapiens 98-103 23743668-7 2013 In addition, the ABCB1 genotype of 36 tacrolimus-treated renal transplant patients was related to ABCB1 activity and tacrolimus efficacy. Tacrolimus 117-127 ATP binding cassette subfamily B member 1 Homo sapiens 17-22 23743668-12 2013 This effect on tacrolimus pharmacodynamics was associated with ABCB1 3435C>T SNP in renal transplant patients: verapamil reduced the percentage of IL-2-producing CD4 and CD8 T cells by 14% and 22% in patients with the CC genotype (P < 0.05) but not in patients with the TT genotype. Tacrolimus 15-25 ATP binding cassette subfamily B member 1 Homo sapiens 63-68 23743668-14 2013 CONCLUSION: The ABCB1 3435C>T SNP influences ABCB1 activity of T cells and the pharmacodynamic effect of tacrolimus in kidney transplant patients. Tacrolimus 108-118 ATP binding cassette subfamily B member 1 Homo sapiens 16-21 23743668-14 2013 CONCLUSION: The ABCB1 3435C>T SNP influences ABCB1 activity of T cells and the pharmacodynamic effect of tacrolimus in kidney transplant patients. Tacrolimus 108-118 ATP binding cassette subfamily B member 1 Homo sapiens 48-53