PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23594311-9 2013 The expression of FasL and activated caspases, particularly caspase-3, was increased, whereas the phosphorylation of PI3K, Akt and NF-kappaB was decreased by GlcN treatment. Glucosamine 158-162 AKT serine/threonine kinase 1 Homo sapiens 123-126 23594311-10 2013 Therefore, in addition to down-regulating TCR signalling and promoting CTLA-4 expression, GlcN may also suppress T cell function by enhancing apoptosis of activated T cells, through both extrinsic and intrinsic apoptotic signalling pathways, which were regulated by the inhibition of PI3K/Akt and NF-kappaB phosphorylation. Glucosamine 90-94 AKT serine/threonine kinase 1 Homo sapiens 289-292