PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23378049-0	2013	TAK1 activates AMPK-dependent cell death pathway in hydrogen peroxide-treated cardiomyocytes, inhibited by heat shock protein-70.	Hydrogen Peroxide	52-69	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	15-19	
23378049-1	2013	The aim of this current study is to investigate the potential role of AMP-activated protein kinase (AMPK) in hydrogen peroxide (H2O2)-induced cardiomyocyte death, and focused on the signaling mechanisms of AMPK activation by H2O2.	Hydrogen Peroxide	109-126	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	70-98	
23378049-1	2013	The aim of this current study is to investigate the potential role of AMP-activated protein kinase (AMPK) in hydrogen peroxide (H2O2)-induced cardiomyocyte death, and focused on the signaling mechanisms of AMPK activation by H2O2.	Hydrogen Peroxide	109-126	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	100-104	
23378049-1	2013	The aim of this current study is to investigate the potential role of AMP-activated protein kinase (AMPK) in hydrogen peroxide (H2O2)-induced cardiomyocyte death, and focused on the signaling mechanisms of AMPK activation by H2O2.	Hydrogen Peroxide	109-126	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	206-210	
23378049-1	2013	The aim of this current study is to investigate the potential role of AMP-activated protein kinase (AMPK) in hydrogen peroxide (H2O2)-induced cardiomyocyte death, and focused on the signaling mechanisms of AMPK activation by H2O2.	Hydrogen Peroxide	128-132	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	70-98	
23378049-1	2013	The aim of this current study is to investigate the potential role of AMP-activated protein kinase (AMPK) in hydrogen peroxide (H2O2)-induced cardiomyocyte death, and focused on the signaling mechanisms of AMPK activation by H2O2.	Hydrogen Peroxide	128-132	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	100-104	
23378049-1	2013	The aim of this current study is to investigate the potential role of AMP-activated protein kinase (AMPK) in hydrogen peroxide (H2O2)-induced cardiomyocyte death, and focused on the signaling mechanisms of AMPK activation by H2O2.	Hydrogen Peroxide	128-132	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	206-210	
23378049-1	2013	The aim of this current study is to investigate the potential role of AMP-activated protein kinase (AMPK) in hydrogen peroxide (H2O2)-induced cardiomyocyte death, and focused on the signaling mechanisms of AMPK activation by H2O2.	Hydrogen Peroxide	225-229	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	70-98	
23378049-1	2013	The aim of this current study is to investigate the potential role of AMP-activated protein kinase (AMPK) in hydrogen peroxide (H2O2)-induced cardiomyocyte death, and focused on the signaling mechanisms of AMPK activation by H2O2.	Hydrogen Peroxide	225-229	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	206-210	
23378049-2	2013	We observed a significant AMPK activation in H2O2-treated cardiomyocytes (both primary cells and H9c2 line).	Hydrogen Peroxide	45-49	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	26-30	
23378049-3	2013	Inhibition of AMPK by its inhibitor or RNAi-reduced H2O2-induced cardiomyocyte death.	Hydrogen Peroxide	52-56	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	14-18	
23378049-4	2013	We here proposed that transforming growth factor-beta-activating kinase 1 (TAK1) might be the upstream kinase for AMPK activation by H2O2.	Hydrogen Peroxide	133-137	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	114-118	
23378049-5	2013	H2O2-induced TAK1 activation, which recruited and activated AMPK.	Hydrogen Peroxide	0-4	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	60-64	
23378049-6	2013	TAK1 inhibitor significantly suppressed H2O2-induced AMPK activation and following cardiomyocyte death, while over-expression of TAK1-facilitated AMPK activation and aggregated cardiomyocyte death.	Hydrogen Peroxide	40-44	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	53-57	
23378049-8	2013	In conclusion, we here suggest that TAK1 activates AMPK-dependent cell death pathway in H2O2-treated cardiomyocytes, and HSP-70 inhibits the signaling pathway by reducing ROS content.	Hydrogen Peroxide	88-92	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	51-55