PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23197749-0 2012 Ataxin-1 and ataxin-2 intermediate-length PolyQ expansions in amyotrophic lateral sclerosis. polyglutamine 42-47 ataxin 2 Homo sapiens 13-21 23197749-1 2012 OBJECTIVE: Recent evidence suggests that intermediate-length polyglutamine (PolyQ) expansions in the ataxin-2 (ATXN-2) gene are a risk factor for amyotrophic lateral sclerosis (ALS). polyglutamine 61-74 ataxin 2 Homo sapiens 101-109 23197749-1 2012 OBJECTIVE: Recent evidence suggests that intermediate-length polyglutamine (PolyQ) expansions in the ataxin-2 (ATXN-2) gene are a risk factor for amyotrophic lateral sclerosis (ALS). polyglutamine 61-74 ataxin 2 Homo sapiens 111-117 23197749-1 2012 OBJECTIVE: Recent evidence suggests that intermediate-length polyglutamine (PolyQ) expansions in the ataxin-2 (ATXN-2) gene are a risk factor for amyotrophic lateral sclerosis (ALS). polyglutamine 76-81 ataxin 2 Homo sapiens 101-109 23197749-1 2012 OBJECTIVE: Recent evidence suggests that intermediate-length polyglutamine (PolyQ) expansions in the ataxin-2 (ATXN-2) gene are a risk factor for amyotrophic lateral sclerosis (ALS). polyglutamine 76-81 ataxin 2 Homo sapiens 111-117 23197749-2 2012 This work was undertaken with the aim to investigate the frequency of ataxin-1 (ATXN-1) and ATXN-2 PolyQ expansions in a cohort of patients with sporadic ALS (sALS) and patients with familial ALS (fALS) from southern Italy. polyglutamine 99-104 ataxin 2 Homo sapiens 92-98 23197749-4 2012 RESULTS: We found significantly higher intermediate PolyQ expansions >= 32 for ATXN-1 alleles and >= 28 for ATXN-2 alleles in the sALS cohort (ATXN-1: ALS, 7.07% vs controls, 2.38%; p = 0.0001; ATXN-2: ALS, 2.72% vs controls, 0.5%; p = 0.001). polyglutamine 52-57 ataxin 2 Homo sapiens 194-200 23197749-7 2012 CONCLUSIONS: Both ATXN-1 and ATXN-2 PolyQ intermediate expansions are independently associated with an increased risk for ALS. polyglutamine 36-41 ataxin 2 Homo sapiens 29-35