PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23070058-1 2013 AIMS/HYPOTHESIS: Downregulation of levels of endothelial progenitor cells (EPCs) during in-vitro short-term exposure to high glucose concentrations relates to reduced activity of silent information regulator 1 (SIRT1) and increased synthesis of platelet-activating factor (PAF). Glucose 125-132 sirtuin 1 Homo sapiens 179-209 23070058-1 2013 AIMS/HYPOTHESIS: Downregulation of levels of endothelial progenitor cells (EPCs) during in-vitro short-term exposure to high glucose concentrations relates to reduced activity of silent information regulator 1 (SIRT1) and increased synthesis of platelet-activating factor (PAF). Glucose 125-132 sirtuin 1 Homo sapiens 211-216 23070058-2 2013 We investigated the possible relationship between PAF and SIRT1 pathways in EPCs during altered glucose homeostasis. Glucose 96-103 sirtuin 1 Homo sapiens 58-63 23070058-5 2013 In-vitro experiments with the PAF-R antagonist CV3988 were performed on EPCs isolated from leucocyte-rich buffy coat of healthy human donors. CV 3988 47-53 platelet activating factor receptor Homo sapiens 30-35 23070058-9 2013 In-vitro experiments confirmed that EPCs respond to PAF stimulation with decreased SIRT1 protein and SIRT1 mRNA levels. Platelet Activating Factor 52-55 sirtuin 1 Homo sapiens 83-88 23070058-9 2013 In-vitro experiments confirmed that EPCs respond to PAF stimulation with decreased SIRT1 protein and SIRT1 mRNA levels. Platelet Activating Factor 52-55 sirtuin 1 Homo sapiens 101-106