PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22966072-5	2012	In muscle cell culture, nicotine exposure significantly increased IRS-1(ser636) phosphorylation and decreased insulin sensitivity, recapitulating the phenotype of smoking-induced insulin resistance in humans.	Nicotine	24-32	insulin	Homo sapiens	110-117	
22966072-5	2012	In muscle cell culture, nicotine exposure significantly increased IRS-1(ser636) phosphorylation and decreased insulin sensitivity, recapitulating the phenotype of smoking-induced insulin resistance in humans.	Nicotine	24-32	insulin	Homo sapiens	179-186	
22966072-7	2012	Inhibition of mTOR, but not p44/42 MAPK, during nicotine exposure prevented IRS-1(ser636) phosphorylation and normalized insulin sensitivity.	Nicotine	48-56	insulin	Homo sapiens	121-128	
22966072-8	2012	These data indicate nicotine induces insulin resistance in skeletal muscle by activating mTOR.	Nicotine	20-28	insulin	Homo sapiens	37-44