PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22962562-4 2012 In this pilot study, changes in p53 and its transcriptional targets, p21/waf1 and MDM2 were analyzed by immunoblotting and densitometry in CLL cells from 10 patients immediately prior to the start of chemotherapy, and after culture for 24 hours (h) with fludarabine (n=7) or chlorambucil (n=3). fludarabine 254-265 tumor protein p53 Homo sapiens 32-35