PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22948162-9 2012 Our findings suggest that NLRP3 is activated by a two-step deubiquitination mechanism initiated by Toll-like receptor signaling and mitochondrial reactive oxygen species and further potentiated by ATP, which could explain how NLRP3 is activated by diverse danger signals. Reactive Oxygen Species 146-169 NLR family pyrin domain containing 3 Homo sapiens 26-31 22948162-9 2012 Our findings suggest that NLRP3 is activated by a two-step deubiquitination mechanism initiated by Toll-like receptor signaling and mitochondrial reactive oxygen species and further potentiated by ATP, which could explain how NLRP3 is activated by diverse danger signals. Reactive Oxygen Species 146-169 NLR family pyrin domain containing 3 Homo sapiens 226-231