PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22807997-0	2012	H2O2 production downstream of FLT3 is mediated by p22phox in the endoplasmic reticulum and is required for STAT5 signalling.	Hydrogen Peroxide	0-4	fms related receptor tyrosine kinase 3	Homo sapiens	30-34	
22807997-0	2012	H2O2 production downstream of FLT3 is mediated by p22phox in the endoplasmic reticulum and is required for STAT5 signalling.	Hydrogen Peroxide	0-4	cytochrome b-245 alpha chain	Homo sapiens	50-57	
22807997-0	2012	H2O2 production downstream of FLT3 is mediated by p22phox in the endoplasmic reticulum and is required for STAT5 signalling.	Hydrogen Peroxide	0-4	signal transducer and activator of transcription 5A	Homo sapiens	107-112	
22807997-1	2012	The internal tandem duplication (ITD) of the juxtamembrane region of the FLT3 receptor has been associated with increased reactive oxygen species (ROS) generation in acute myeloid leukemia (AML).	Reactive Oxygen Species	122-145	fms related receptor tyrosine kinase 3	Homo sapiens	73-77	
22807997-1	2012	The internal tandem duplication (ITD) of the juxtamembrane region of the FLT3 receptor has been associated with increased reactive oxygen species (ROS) generation in acute myeloid leukemia (AML).	Reactive Oxygen Species	147-150	fms related receptor tyrosine kinase 3	Homo sapiens	73-77	
22807997-3	2012	In this work we show that ROS in the FLT3-ITD expressing AML cell line MV4-11 is reduced by treatment with PKC412, an inhibitor of FLT3, DPI, a flavoprotein inhibitor, and VAS2870, a Nox specific inhibitor, suggesting that ROS production is both FLT3 and NADPH oxidase dependent.	Reactive Oxygen Species	26-29	fms related receptor tyrosine kinase 3	Homo sapiens	37-41	
22807997-3	2012	In this work we show that ROS in the FLT3-ITD expressing AML cell line MV4-11 is reduced by treatment with PKC412, an inhibitor of FLT3, DPI, a flavoprotein inhibitor, and VAS2870, a Nox specific inhibitor, suggesting that ROS production is both FLT3 and NADPH oxidase dependent.	Reactive Oxygen Species	26-29	fms related receptor tyrosine kinase 3	Homo sapiens	131-135	
22807997-3	2012	In this work we show that ROS in the FLT3-ITD expressing AML cell line MV4-11 is reduced by treatment with PKC412, an inhibitor of FLT3, DPI, a flavoprotein inhibitor, and VAS2870, a Nox specific inhibitor, suggesting that ROS production is both FLT3 and NADPH oxidase dependent.	Reactive Oxygen Species	26-29	fms related receptor tyrosine kinase 3	Homo sapiens	131-135	
22807997-3	2012	In this work we show that ROS in the FLT3-ITD expressing AML cell line MV4-11 is reduced by treatment with PKC412, an inhibitor of FLT3, DPI, a flavoprotein inhibitor, and VAS2870, a Nox specific inhibitor, suggesting that ROS production is both FLT3 and NADPH oxidase dependent.	mv4-11	71-77	fms related receptor tyrosine kinase 3	Homo sapiens	37-41	
22807997-3	2012	In this work we show that ROS in the FLT3-ITD expressing AML cell line MV4-11 is reduced by treatment with PKC412, an inhibitor of FLT3, DPI, a flavoprotein inhibitor, and VAS2870, a Nox specific inhibitor, suggesting that ROS production is both FLT3 and NADPH oxidase dependent.	mv4-11	71-77	fms related receptor tyrosine kinase 3	Homo sapiens	131-135	
22807997-3	2012	In this work we show that ROS in the FLT3-ITD expressing AML cell line MV4-11 is reduced by treatment with PKC412, an inhibitor of FLT3, DPI, a flavoprotein inhibitor, and VAS2870, a Nox specific inhibitor, suggesting that ROS production is both FLT3 and NADPH oxidase dependent.	mv4-11	71-77	fms related receptor tyrosine kinase 3	Homo sapiens	131-135	
22807997-3	2012	In this work we show that ROS in the FLT3-ITD expressing AML cell line MV4-11 is reduced by treatment with PKC412, an inhibitor of FLT3, DPI, a flavoprotein inhibitor, and VAS2870, a Nox specific inhibitor, suggesting that ROS production is both FLT3 and NADPH oxidase dependent.	3-aminodiphenyleneiodium	137-140	fms related receptor tyrosine kinase 3	Homo sapiens	37-41	
22807997-3	2012	In this work we show that ROS in the FLT3-ITD expressing AML cell line MV4-11 is reduced by treatment with PKC412, an inhibitor of FLT3, DPI, a flavoprotein inhibitor, and VAS2870, a Nox specific inhibitor, suggesting that ROS production is both FLT3 and NADPH oxidase dependent.	3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine	172-179	fms related receptor tyrosine kinase 3	Homo sapiens	37-41	
22807997-3	2012	In this work we show that ROS in the FLT3-ITD expressing AML cell line MV4-11 is reduced by treatment with PKC412, an inhibitor of FLT3, DPI, a flavoprotein inhibitor, and VAS2870, a Nox specific inhibitor, suggesting that ROS production is both FLT3 and NADPH oxidase dependent.	nicotine 1-N-oxide	183-186	fms related receptor tyrosine kinase 3	Homo sapiens	37-41	
22807997-3	2012	In this work we show that ROS in the FLT3-ITD expressing AML cell line MV4-11 is reduced by treatment with PKC412, an inhibitor of FLT3, DPI, a flavoprotein inhibitor, and VAS2870, a Nox specific inhibitor, suggesting that ROS production is both FLT3 and NADPH oxidase dependent.	nicotine 1-N-oxide	183-186	fms related receptor tyrosine kinase 3	Homo sapiens	131-135	
22807997-3	2012	In this work we show that ROS in the FLT3-ITD expressing AML cell line MV4-11 is reduced by treatment with PKC412, an inhibitor of FLT3, DPI, a flavoprotein inhibitor, and VAS2870, a Nox specific inhibitor, suggesting that ROS production is both FLT3 and NADPH oxidase dependent.	nicotine 1-N-oxide	183-186	fms related receptor tyrosine kinase 3	Homo sapiens	131-135	
22807997-3	2012	In this work we show that ROS in the FLT3-ITD expressing AML cell line MV4-11 is reduced by treatment with PKC412, an inhibitor of FLT3, DPI, a flavoprotein inhibitor, and VAS2870, a Nox specific inhibitor, suggesting that ROS production is both FLT3 and NADPH oxidase dependent.	Reactive Oxygen Species	223-226	fms related receptor tyrosine kinase 3	Homo sapiens	37-41	
22807997-3	2012	In this work we show that ROS in the FLT3-ITD expressing AML cell line MV4-11 is reduced by treatment with PKC412, an inhibitor of FLT3, DPI, a flavoprotein inhibitor, and VAS2870, a Nox specific inhibitor, suggesting that ROS production is both FLT3 and NADPH oxidase dependent.	Reactive Oxygen Species	223-226	fms related receptor tyrosine kinase 3	Homo sapiens	131-135	
22807997-3	2012	In this work we show that ROS in the FLT3-ITD expressing AML cell line MV4-11 is reduced by treatment with PKC412, an inhibitor of FLT3, DPI, a flavoprotein inhibitor, and VAS2870, a Nox specific inhibitor, suggesting that ROS production is both FLT3 and NADPH oxidase dependent.	Reactive Oxygen Species	223-226	fms related receptor tyrosine kinase 3	Homo sapiens	131-135	
22807997-4	2012	The majority of these ROS co-localize to the endoplasmic reticulum (ER), as determined with the H(2)O(2)-specific aryl-boronate dye Peroxyorange 1, which also corresponds to co-localization of p22phox.	Reactive Oxygen Species	22-25	cytochrome b-245 alpha chain	Homo sapiens	193-200	
22807997-4	2012	The majority of these ROS co-localize to the endoplasmic reticulum (ER), as determined with the H(2)O(2)-specific aryl-boronate dye Peroxyorange 1, which also corresponds to co-localization of p22phox.	aryl-boronate	114-127	cytochrome b-245 alpha chain	Homo sapiens	193-200	
22807997-6	2012	Significantly, the FLT3 inhibitor PKC412 reduces H(2)O(2) in FLT3-ITD expressing cell lines (MV4-11, MOLM-13) through reduction of p22phox over 24 hours.	Hydrogen Peroxide	49-57	fms related receptor tyrosine kinase 3	Homo sapiens	19-23	
22807997-6	2012	Significantly, the FLT3 inhibitor PKC412 reduces H(2)O(2) in FLT3-ITD expressing cell lines (MV4-11, MOLM-13) through reduction of p22phox over 24 hours.	Hydrogen Peroxide	49-57	fms related receptor tyrosine kinase 3	Homo sapiens	61-65	
22807997-9	2012	Thus, we have shown that FLT3 driven H(2)O(2) production in AML cells is mediated by p22phox and is critical for STAT5 signalling.	Hydrogen Peroxide	37-45	fms related receptor tyrosine kinase 3	Homo sapiens	25-29	
22807997-9	2012	Thus, we have shown that FLT3 driven H(2)O(2) production in AML cells is mediated by p22phox and is critical for STAT5 signalling.	Hydrogen Peroxide	37-45	cytochrome b-245 alpha chain	Homo sapiens	85-92	
22807997-9	2012	Thus, we have shown that FLT3 driven H(2)O(2) production in AML cells is mediated by p22phox and is critical for STAT5 signalling.	Hydrogen Peroxide	37-45	signal transducer and activator of transcription 5A	Homo sapiens	113-118