PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22721392-0 2013 The role of autophagic cell death and apoptosis in irinotecan-treated p53 null colon cancer cells. Irinotecan 51-61 tumor protein p53 Homo sapiens 70-73 22721392-1 2013 The roles of autophagic cell death and apoptosis induced by topoisomerase inhibitor irinotecan in colon cancer cells with deleted p53 were investigated during 48 h. We report that irinotecan-dependent cytotoxicity and proapoptotic activity were reduced in the present model while autophagy levels significantly increased. Irinotecan 180-190 tumor protein p53 Homo sapiens 130-133 22721392-4 2013 These results suggest that different modes of cell death in p53 null colon cancer cells treated with cytostatics (irinotecan) may be activated simultaneously. Irinotecan 114-124 tumor protein p53 Homo sapiens 60-63