PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22585829-0 2012 Resveratrol stimulates cortisol biosynthesis by activating SIRT-dependent deacetylation of P450scc. Resveratrol 0-11 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 91-98 22585829-0 2012 Resveratrol stimulates cortisol biosynthesis by activating SIRT-dependent deacetylation of P450scc. Hydrocortisone 23-31 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 91-98 22585829-4 2012 We show that resveratrol increases the protein expression and half-life of P450 side chain cleavage enzyme (P450scc). Resveratrol 13-24 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 75-106 22585829-4 2012 We show that resveratrol increases the protein expression and half-life of P450 side chain cleavage enzyme (P450scc). Resveratrol 13-24 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 108-115 22585829-5 2012 The effects of resveratrol on P450scc protein levels and acetylation status are dependent on SIRT3 and SIRT5 expression. Resveratrol 15-26 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 30-37 22585829-5 2012 The effects of resveratrol on P450scc protein levels and acetylation status are dependent on SIRT3 and SIRT5 expression. Resveratrol 15-26 sirtuin 3 Homo sapiens 93-98 22585829-5 2012 The effects of resveratrol on P450scc protein levels and acetylation status are dependent on SIRT3 and SIRT5 expression. Resveratrol 15-26 sirtuin 5 Homo sapiens 103-108 22585829-7 2012 Mutation of K148 and K149 to alanine stabilizes the expression of P450scc and results in a 1.5-fold increase in pregnenolone biosynthesis. Alanine 29-36 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 66-73 22585829-7 2012 Mutation of K148 and K149 to alanine stabilizes the expression of P450scc and results in a 1.5-fold increase in pregnenolone biosynthesis. Pregnenolone 112-124 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 66-73