PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22583617-0 2012 E297G mutated bile salt export pump (BSEP) function enhancers derived from GW4064: structural development study and separation from farnesoid X receptor-agonistic activity. GW 4064 75-81 ATP binding cassette subfamily B member 11 Homo sapiens 14-35 22583617-0 2012 E297G mutated bile salt export pump (BSEP) function enhancers derived from GW4064: structural development study and separation from farnesoid X receptor-agonistic activity. GW 4064 75-81 ATP binding cassette subfamily B member 11 Homo sapiens 37-41 22583617-3 2012 We previously found that compounds based on GW4064, a representative farnesoid X receptor (FXR) agonist, enhanced E297G BSEP transport activity. GW 4064 44-50 ATP binding cassette subfamily B member 11 Homo sapiens 120-124 22583617-4 2012 Here, we conducted a structure-activity relationship analysis of GW4064 derivatives aimed at separating E297G BSEP-function-promoting activity and FXR-agonistic activity. GW 4064 65-71 ATP binding cassette subfamily B member 11 Homo sapiens 110-114 22583617-5 2012 Among newly synthesized reversed-amide derivatives of previously reported GW4064 analogs 2a-2f, we identified 7c as a selective BSEP function enhancer. GW 4064 74-80 ATP binding cassette subfamily B member 11 Homo sapiens 128-132