PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22277574-0	2013	Pioglitazone ameliorates systolic and diastolic cardiac dysfunction in rat model of angiotensin II-induced hypertension.	Pioglitazone	0-12	angiotensinogen	Rattus norvegicus	84-98	
22277574-2	2013	In the current study, we examined the effect of pioglitazone, an agonist of peroxisome proliferator activated receptor-gamma, on angiotensin II-induced intracardiac lipid accumulation and cardiac dysfunction.	Pioglitazone	48-60	angiotensinogen	Rattus norvegicus	129-143	
22277574-3	2013	Pioglitazone, given orally at a dose of 2.5mg/kg/d, reduced cardiac triglyceride content and suppressed lipid deposition in the heart of angiotensin II-induced hypertensive rats without affecting angiotensin II-induced upregulation of lipogenic gene expression.	Pioglitazone	0-12	angiotensinogen	Rattus norvegicus	137-151	
22277574-4	2013	Histological examination showed that pioglitazone reduced the area of cardiac fibrosis and iron deposition in the heart of angiotensin II-treated rats.	Pioglitazone	37-49	angiotensinogen	Rattus norvegicus	123-137	
22277574-6	2013	Angiotensin II increased the superoxide signals detected by dihydroethidium staining in myocardial cells with lipid deposition, and this increase was suppressed by pioglitazone.	Pioglitazone	164-176	angiotensinogen	Rattus norvegicus	0-14	
22277574-8	2013	It was found that pioglitazone improved both the systolic and diastolic cardiac performance, which was weakened by angiotensin II infusion, after transient ischemia and reperfusion.	Pioglitazone	18-30	angiotensinogen	Rattus norvegicus	115-129	
22277574-9	2013	These findings collectively suggest that pioglitazone treatment ameliorated the histological and functional cardiac damage induced by angiotensin II infusion, the mechanism of which may be related to the antioxidative action of pioglitazone.	Pioglitazone	41-53	angiotensinogen	Rattus norvegicus	134-148	
22277574-9	2013	These findings collectively suggest that pioglitazone treatment ameliorated the histological and functional cardiac damage induced by angiotensin II infusion, the mechanism of which may be related to the antioxidative action of pioglitazone.	Pioglitazone	228-240	angiotensinogen	Rattus norvegicus	134-148