PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22073424-6 2004 For this, investigators developed gadolinium-bis-5-hydroxytriptamide-diethylenetriamine pentaacetic acid (Gd-bis-5-HT-DTPA; also known as MPO-Gd), a magnetic resonance imaging (MRI) agent, that acts as a substrate for the MPO and used it for the noninvasive visualization of MPO activity in normal and diseased tissues (3). gd-bis-5-ht-dtpa 106-122 myeloperoxidase Homo sapiens 138-141 22073424-6 2004 For this, investigators developed gadolinium-bis-5-hydroxytriptamide-diethylenetriamine pentaacetic acid (Gd-bis-5-HT-DTPA; also known as MPO-Gd), a magnetic resonance imaging (MRI) agent, that acts as a substrate for the MPO and used it for the noninvasive visualization of MPO activity in normal and diseased tissues (3). gd-bis-5-ht-dtpa 106-122 myeloperoxidase Homo sapiens 222-225 22073424-6 2004 For this, investigators developed gadolinium-bis-5-hydroxytriptamide-diethylenetriamine pentaacetic acid (Gd-bis-5-HT-DTPA; also known as MPO-Gd), a magnetic resonance imaging (MRI) agent, that acts as a substrate for the MPO and used it for the noninvasive visualization of MPO activity in normal and diseased tissues (3). gd-bis-5-ht-dtpa 106-122 myeloperoxidase Homo sapiens 222-225 22073424-7 2004 Oxidative activation of the paramagnetic substrate (Gd-bis-5-HT-DTPA) by MPO leads to oligomerization and entrapment of the activated Gd-bis-5-HT-DTPA within the tissue by cross-linking the monomer or the oligomer with tyrosine-containing proteins, thereby increasing the localized concentration Gd at the site of MPO activity as explained in detail by Rodriguez et al. gd-bis-5-ht-dtpa 52-68 myeloperoxidase Homo sapiens 73-76 22073424-7 2004 Oxidative activation of the paramagnetic substrate (Gd-bis-5-HT-DTPA) by MPO leads to oligomerization and entrapment of the activated Gd-bis-5-HT-DTPA within the tissue by cross-linking the monomer or the oligomer with tyrosine-containing proteins, thereby increasing the localized concentration Gd at the site of MPO activity as explained in detail by Rodriguez et al. gd-bis-5-ht-dtpa 52-68 myeloperoxidase Homo sapiens 314-317 22073424-7 2004 Oxidative activation of the paramagnetic substrate (Gd-bis-5-HT-DTPA) by MPO leads to oligomerization and entrapment of the activated Gd-bis-5-HT-DTPA within the tissue by cross-linking the monomer or the oligomer with tyrosine-containing proteins, thereby increasing the localized concentration Gd at the site of MPO activity as explained in detail by Rodriguez et al. gd-bis-5-ht-dtpa 134-150 myeloperoxidase Homo sapiens 73-76 22073424-7 2004 Oxidative activation of the paramagnetic substrate (Gd-bis-5-HT-DTPA) by MPO leads to oligomerization and entrapment of the activated Gd-bis-5-HT-DTPA within the tissue by cross-linking the monomer or the oligomer with tyrosine-containing proteins, thereby increasing the localized concentration Gd at the site of MPO activity as explained in detail by Rodriguez et al. gd-bis-5-ht-dtpa 134-150 myeloperoxidase Homo sapiens 314-317 22073424-9 2004 In addition, the oligomeric and entrapped Gd-bis-5-HT-DTPA has a slow clearance rate from the tissue compared to the non-activated compound, and delayed clearance of the activated Gd-bis-5-HT-DTPA allows for the imaging of MPO in the inflamed tissue. gd-bis-5-ht-dtpa 42-58 myeloperoxidase Homo sapiens 223-226 22073424-9 2004 In addition, the oligomeric and entrapped Gd-bis-5-HT-DTPA has a slow clearance rate from the tissue compared to the non-activated compound, and delayed clearance of the activated Gd-bis-5-HT-DTPA allows for the imaging of MPO in the inflamed tissue. gd-bis-5-ht-dtpa 180-196 myeloperoxidase Homo sapiens 223-226