PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21993412-0	2011	Antiplatelet effect by p-cresol, a uremic and environmental toxicant, is related to inhibition of reactive oxygen species, ERK/p38 signaling and thromboxane A2 production.	4-cresol	23-31	mitogen-activated protein kinase 3	Homo sapiens	123-126	
21993412-0	2011	Antiplatelet effect by p-cresol, a uremic and environmental toxicant, is related to inhibition of reactive oxygen species, ERK/p38 signaling and thromboxane A2 production.	4-cresol	23-31	mitogen-activated protein kinase 1	Homo sapiens	127-130	
21993412-2	2011	In this study, p-cresol (1-5 muM) inhibited the arachidonic acid (AA)-induced platelet aggregation, with 47% and 82% of inhibition at concentrations of 2 and 5 muM, respectively.	4-cresol	15-23	latexin	Homo sapiens	29-32	
21993412-2	2011	In this study, p-cresol (1-5 muM) inhibited the arachidonic acid (AA)-induced platelet aggregation, with 47% and 82% of inhibition at concentrations of 2 and 5 muM, respectively.	4-cresol	15-23	latexin	Homo sapiens	160-163	
21993412-6	2011	P-cresol (2-100 muM) partly inhibited the AA-induced reactive oxygen species (ROS) production as well as the extracellular signal-regulated kinase (ERK1/2) and p38 phosphorylation in platelets.	4-cresol	0-8	latexin	Homo sapiens	16-19	
21993412-6	2011	P-cresol (2-100 muM) partly inhibited the AA-induced reactive oxygen species (ROS) production as well as the extracellular signal-regulated kinase (ERK1/2) and p38 phosphorylation in platelets.	4-cresol	0-8	mitogen-activated protein kinase 3	Homo sapiens	148-154	
21993412-6	2011	P-cresol (2-100 muM) partly inhibited the AA-induced reactive oxygen species (ROS) production as well as the extracellular signal-regulated kinase (ERK1/2) and p38 phosphorylation in platelets.	4-cresol	0-8	mitogen-activated protein kinase 1	Homo sapiens	160-163	
21993412-7	2011	P-cresol further inhibited the AA-induced aggregation of rabbit platelet-rich plasma (PRP) with an IC50 of 2 muM and aggregation of human PRP (IC50 = 13.6 muM).	4-cresol	0-8	latexin	Homo sapiens	109-112	
21993412-7	2011	P-cresol further inhibited the AA-induced aggregation of rabbit platelet-rich plasma (PRP) with an IC50 of 2 muM and aggregation of human PRP (IC50 = 13.6 muM).	4-cresol	0-8	latexin	Homo sapiens	155-158	
21993412-8	2011	Intravenous administration of p-cresol (250-1000 nmole) into mice effectively suppressed the ex vivo platelet aggregation, whereas showed little effect on the value of RBC, hemoglobin (HGB), hematocrit, MCV, MCH, MCHC, platelets and lymphocyte counts.	4-cresol	30-38	modifier of chinchilla	Mus musculus	208-211	
21993412-9	2011	These results indicate that in acute p-cresol-poisoning and long-term exposure to cresol as in severe uremic patients, p-cresol may potentially inhibit blood clot formation and lead to hemorrhagic disorders via inhibition of platelet aggregation, ROS production, ERK/p38 activation and TXA(2) production.	4-cresol	119-127	mitogen-activated protein kinase 3	Homo sapiens	263-266	
21993412-9	2011	These results indicate that in acute p-cresol-poisoning and long-term exposure to cresol as in severe uremic patients, p-cresol may potentially inhibit blood clot formation and lead to hemorrhagic disorders via inhibition of platelet aggregation, ROS production, ERK/p38 activation and TXA(2) production.	4-cresol	119-127	mitogen-activated protein kinase 1	Homo sapiens	267-270