PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21747048-1 2011 Genetic variations in the CYP2A6 nicotine metabolic gene and the CHRNA5-CHRNA3-CHRNB4 (CHRNA5-A3-B4) nicotinic gene cluster have been independently associated with lung cancer. Nicotine 33-41 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 26-32 21747048-5 2011 Cigarette consumption (P < .001) and nicotine dependence (P = .036) were the highest in the combined CYP2A6 normal metabolizers and CHRNA5-A3-B4 AA (tag single-nucleotide polymorphism rs1051730 G>A) risk group. Nicotine 40-48 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 104-110 21747048-7 2011 Variation in CYP2A6 and CHRNA5-A3-B4 was independently and additively associated with increased cigarette consumption, nicotine dependence, and lung cancer risk. Nicotine 119-127 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 13-19