PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21543742-0	2011	An intramolecular transport metabolon: fusion of carbonic anhydrase II to the COOH terminus of the Cl(-)/HCO(3)(-)exchanger, AE1.	Bicarbonates	105-110	carbonic anhydrase 2	Homo sapiens	49-70	
21543742-5	2011	When expressed in transfected human embryonic kidney 293 cells, AE1.CAII had a similar Cl(-)/HCO(3)(-) exchange activity to AE1 alone, as assessed by the flux of H(+) equivalents (87 +- 4% vs. AE1) or rate of change of intracellular Cl(-) concentration (93 +- 4% vs. AE1), suggesting that CAII does not activate AE1.	Bicarbonates	93-99	carbonic anhydrase 2	Homo sapiens	68-72	
21543742-7	2011	Fusion of CAII to AE1 therefore reduces anion transport activity, but this reduction is compensated for during Cl(-)/HCO(3)(-) exchange by the presence of catalytically active CAII.	Bicarbonates	117-123	carbonic anhydrase 2	Homo sapiens	10-14	
21543742-7	2011	Fusion of CAII to AE1 therefore reduces anion transport activity, but this reduction is compensated for during Cl(-)/HCO(3)(-) exchange by the presence of catalytically active CAII.	Bicarbonates	117-123	carbonic anhydrase 2	Homo sapiens	176-180	
21543742-8	2011	Overexpression of free CAII-V143Y acts in a dominant negative manner to reduce AE1-mediated HCO(3)(-) transport by displacement of endogenous CAII-wild type from its binding site on AE1.	Bicarbonates	92-98	carbonic anhydrase 2	Homo sapiens	23-27	
21543742-8	2011	Overexpression of free CAII-V143Y acts in a dominant negative manner to reduce AE1-mediated HCO(3)(-) transport by displacement of endogenous CAII-wild type from its binding site on AE1.	Bicarbonates	92-98	carbonic anhydrase 2	Homo sapiens	142-146	
21543742-10	2011	The bicarbonate transport activity of AE1 was inhibited by CAII-V143Y, whereas the activity of AE1.CAII was unaffected by CAII-V143Y, suggesting impaired transport activity upon displacement of functional CAII from AE1 but not AE1.CAII.	Bicarbonates	4-15	carbonic anhydrase 2	Homo sapiens	59-63