PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21531298-0	2011	Feasibility of a novel positive feedback effect of 131I-promoted Bac-Egr1-hNIS expression in malignant glioma via baculovirus.	Iodine-131	51-55	early growth response 1	Homo sapiens	69-73	
21531298-2	2011	As Egr1 promoter is activated by 131I and may promote human NIS (hNIS) expression, hNIS also induces 131I uptake and activates Egr1, so the existence of a positive feedback effect of 131I-promoted Egr1-hNIS expression is possible.	Iodine-131	33-37	early growth response 1	Homo sapiens	3-7	
21531298-5	2011	To test 131I-promoted hNIS expression, human malignant glioma U87 cells were transfected with Bac-Egr1-hNIS, stimulated with or without 131I; the expression of hNIS protein was detected by immunofluorescence and flow cytometry test.	Iodine-131	8-12	early growth response 1	Homo sapiens	98-102	
21531298-6	2011	In addition, the uptake and efflux of 131I were determined after the incubation of Bac-Egr1-hNIS-transfected U87 cells with or without 131I.	Iodine-131	38-42	early growth response 1	Homo sapiens	87-91	
21531298-11	2011	CONCLUSION: Our results indicated that an improved transgene expression of 131I-stimulated hNIS in U87 cells using a baculovirus vector containing the Egr1 promoter is possible, and the increased expression of hNIS is responsible for a higher 131I uptake.	Iodine-131	75-79	early growth response 1	Homo sapiens	151-155