PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21493670-0 2011 Bile acid receptor agonist GW4064 regulates PPARgamma coactivator-1alpha expression through estrogen receptor-related receptor alpha. GW 4064 27-33 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 44-72 21493670-3 2011 In our effort to identify new regulators of PGC-1alpha expression, we found that GW4064, a widely used synthetic agonist for the nuclear bile acid receptor [farnesoid X receptor (FXR)] strongly enhances PGC-1alpha promoter reporter activity, mRNA, and protein expression. GW 4064 81-87 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 44-54 21493670-3 2011 In our effort to identify new regulators of PGC-1alpha expression, we found that GW4064, a widely used synthetic agonist for the nuclear bile acid receptor [farnesoid X receptor (FXR)] strongly enhances PGC-1alpha promoter reporter activity, mRNA, and protein expression. GW 4064 81-87 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 203-213 21493670-7 2011 Interestingly, FXR disruption alters GW4064 induction of PGC-1alpha mRNA in a tissue-dependent manner. GW 4064 37-43 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 57-67 21493670-8 2011 Using FXR-null [FXR knockout (FXRKO)] mice, we determined that GW4064 induction of PGC-1alpha expression is not affected in oxidative soleus muscles of FXRKO mice but is compromised in the FXRKO liver. GW 4064 63-69 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 83-93