PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21357734-2 2011 A Per-Arnt-Sim (PAS) domain in the cytoplasmic N-terminal region of hERG regulates slow deactivation by making a direct interaction with another part of the hERG channel. Aminosalicylic Acid 16-19 ETS transcription factor ERG Homo sapiens 68-72 21357734-2 2011 A Per-Arnt-Sim (PAS) domain in the cytoplasmic N-terminal region of hERG regulates slow deactivation by making a direct interaction with another part of the hERG channel. Aminosalicylic Acid 16-19 ETS transcription factor ERG Homo sapiens 157-161 21357734-5 2011 We report that hERG channels with deletions of the cyclic nucleotide-binding domain (CNBD) had accelerated deactivation kinetics that were similar to those seen in hERG channels lacking the PAS domain. Aminosalicylic Acid 190-193 ETS transcription factor ERG Homo sapiens 15-19 21357734-10 2011 Together, these data suggest that the mechanism for regulation of slow deactivation in hERG channels is an interaction between the N-terminal PAS domain and the C-terminal CNBD. Aminosalicylic Acid 142-145 ETS transcription factor ERG Homo sapiens 87-91