PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21325074-2 2011 Sunitinib, a potent inhibitor of RET, VEGF receptor (VEGFR)-1, VEGFR-2, VEGFR-3, and platelet-derived growth factor receptor (PDGFR)alpha/beta, has been reported as clinically effective in some patients with advanced MTC. Sunitinib 0-9 ret proto-oncogene Homo sapiens 33-36 21325074-4 2011 EXPERIMENTAL DESIGN: Both in vitro and in vivo assays, using the human TT RET(C634W) MTC cell line, were done to assess the activity of sunitinib. Sunitinib 136-145 ret proto-oncogene Homo sapiens 74-77 21325074-6 2011 RESULTS: Sunitinib displayed antiproliferative and antiangiogenic activities and inhibited RET autophosphorylation and activation of downstream signaling pathways. Sunitinib 9-18 ret proto-oncogene Homo sapiens 91-94