PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20931131-9 2011 The effect of this compound was dramatically increased when used in combination with chemotherapeutic drug and/or the HDAC inhibitor Trichostatin A, confirming a proposed synergistic mechanism of p53 deacetylation by SIRT1 and Type I/II HDACs. trichostatin A 133-147 tumor protein p53 Homo sapiens 196-199