PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20844246-4	2010	Real-time quantitative PCR and Western blotting revealed that treatment with BMP4 (50 ng/ml, 60 h) increased TRPC1, TRPC4, and TRPC6 mRNA and protein expression in growth-arrested rat distal PASMCs.	pasmcs	191-197	bone morphogenetic protein 4	Rattus norvegicus	77-81	
20844246-5	2010	Moreover, in comparison to vehicle control, cells treated with BMP4 also exhibited enhanced SOCE, and elevated basal intracellular calcium concentration ([Ca(2+)](i)) as determined by fluorescent microscopy using the Ca(2+) indicator Fura-2 AM.	Calcium	131-138	bone morphogenetic protein 4	Rattus norvegicus	63-67	
20844246-5	2010	Moreover, in comparison to vehicle control, cells treated with BMP4 also exhibited enhanced SOCE, and elevated basal intracellular calcium concentration ([Ca(2+)](i)) as determined by fluorescent microscopy using the Ca(2+) indicator Fura-2 AM.	fura-2-am	234-243	bone morphogenetic protein 4	Rattus norvegicus	63-67	
20844246-6	2010	Perfusing cells with Ca(2+)-free Krebs-Ringer bicarbonate solution (KRBS) or KRBS containing SOCC antagonists SKF-96365 or NiCl(2) attenuated the increases in basal [Ca(2+)](i) caused by BMP4.	krebs	33-38	bone morphogenetic protein 4	Rattus norvegicus	187-191	
20844246-6	2010	Perfusing cells with Ca(2+)-free Krebs-Ringer bicarbonate solution (KRBS) or KRBS containing SOCC antagonists SKF-96365 or NiCl(2) attenuated the increases in basal [Ca(2+)](i) caused by BMP4.	krbs	77-81	bone morphogenetic protein 4	Rattus norvegicus	187-191	
20844246-6	2010	Perfusing cells with Ca(2+)-free Krebs-Ringer bicarbonate solution (KRBS) or KRBS containing SOCC antagonists SKF-96365 or NiCl(2) attenuated the increases in basal [Ca(2+)](i) caused by BMP4.	1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole	110-119	bone morphogenetic protein 4	Rattus norvegicus	187-191	
20844246-6	2010	Perfusing cells with Ca(2+)-free Krebs-Ringer bicarbonate solution (KRBS) or KRBS containing SOCC antagonists SKF-96365 or NiCl(2) attenuated the increases in basal [Ca(2+)](i) caused by BMP4.	nicl	123-127	bone morphogenetic protein 4	Rattus norvegicus	187-191	
20844246-7	2010	Specific knockdown of BMP4 by small interference RNA significantly decreased the mRNA and protein expression of TRPC1, TRPC4, and TRPC6 and reduced SOCE and basal [Ca(2+)](i) in serum-stimulated PASMCs.	pasmcs	195-201	bone morphogenetic protein 4	Rattus norvegicus	22-26	
20844246-8	2010	We conclude that BMP4 regulates calcium signaling in PASMCs likely via upregulation of TRPC expression, leading to enhanced SOCE and basal [Ca(2+)](i) in PASMCs, and by this mechanism contributes to pulmonary vascular remodeling during pulmonary arterial hypertension.	Calcium	32-39	bone morphogenetic protein 4	Rattus norvegicus	17-21	
20844246-8	2010	We conclude that BMP4 regulates calcium signaling in PASMCs likely via upregulation of TRPC expression, leading to enhanced SOCE and basal [Ca(2+)](i) in PASMCs, and by this mechanism contributes to pulmonary vascular remodeling during pulmonary arterial hypertension.	pasmcs	53-59	bone morphogenetic protein 4	Rattus norvegicus	17-21