PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20692795-0	2010	Ellagic acid inhibits oxidized LDL-mediated LOX-1 expression, ROS generation, and inflammation in human endothelial cells.	Ellagic Acid	0-12	oxidized low density lipoprotein receptor 1	Homo sapiens	44-49	
20692795-2	2010	Expression of LOX-1 is involved in the pathobiological effects of oxLDL in endothelial cells, including reactive oxygen species (ROS) generation, suppression of endothelial nitric oxide synthase (eNOS) activity, and leukocytic adhesion.	Reactive Oxygen Species	104-127	oxidized low density lipoprotein receptor 1	Homo sapiens	14-19	
20692795-2	2010	Expression of LOX-1 is involved in the pathobiological effects of oxLDL in endothelial cells, including reactive oxygen species (ROS) generation, suppression of endothelial nitric oxide synthase (eNOS) activity, and leukocytic adhesion.	Reactive Oxygen Species	129-132	oxidized low density lipoprotein receptor 1	Homo sapiens	14-19	
20692795-4	2010	In this study, we determined whether ellagic acid, a polyphenolic compound widely distributed in fruits and nuts, protects against oxLDL-induced endothelial dysfunction by modulating the LOX-1-mediated signaling pathway.	Ellagic Acid	37-49	oxidized low density lipoprotein receptor 1	Homo sapiens	187-192	
20692795-6	2010	RESULTS: LOX-1 protein expression was markedly lower after exposure to oxLDL in HUVECs pretreated with ellagic acid or diphenyleneiodonium, a well-known inhibitor of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, than in HUVECs exposed to oxLDL alone, suggesting that ellagic acid deactivates NADPH oxidase.	Ellagic Acid	103-115	oxidized low density lipoprotein receptor 1	Homo sapiens	9-14	
20692795-6	2010	RESULTS: LOX-1 protein expression was markedly lower after exposure to oxLDL in HUVECs pretreated with ellagic acid or diphenyleneiodonium, a well-known inhibitor of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, than in HUVECs exposed to oxLDL alone, suggesting that ellagic acid deactivates NADPH oxidase.	diphenyleneiodonium	119-138	oxidized low density lipoprotein receptor 1	Homo sapiens	9-14	
20692795-6	2010	RESULTS: LOX-1 protein expression was markedly lower after exposure to oxLDL in HUVECs pretreated with ellagic acid or diphenyleneiodonium, a well-known inhibitor of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, than in HUVECs exposed to oxLDL alone, suggesting that ellagic acid deactivates NADPH oxidase.	NAD	166-199	oxidized low density lipoprotein receptor 1	Homo sapiens	9-14	
20692795-6	2010	RESULTS: LOX-1 protein expression was markedly lower after exposure to oxLDL in HUVECs pretreated with ellagic acid or diphenyleneiodonium, a well-known inhibitor of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, than in HUVECs exposed to oxLDL alone, suggesting that ellagic acid deactivates NADPH oxidase.	Ellagic Acid	282-294	oxidized low density lipoprotein receptor 1	Homo sapiens	9-14	
20692795-7	2010	We also found that oxLDL activated the membrane assembly of p47phox, Rac1, gp91 and p22phox, and the subsequent induction of ROS generation; however, ROS generation was markedly suppressed in cells pretreated with ellagic acid or anti-LOX-1 monoclonal antibody.	Reactive Oxygen Species	150-153	oxidized low density lipoprotein receptor 1	Homo sapiens	235-240	
20692795-7	2010	We also found that oxLDL activated the membrane assembly of p47phox, Rac1, gp91 and p22phox, and the subsequent induction of ROS generation; however, ROS generation was markedly suppressed in cells pretreated with ellagic acid or anti-LOX-1 monoclonal antibody.	Ellagic Acid	214-226	neutrophil cytosolic factor 1	Homo sapiens	60-67	
20692795-7	2010	We also found that oxLDL activated the membrane assembly of p47phox, Rac1, gp91 and p22phox, and the subsequent induction of ROS generation; however, ROS generation was markedly suppressed in cells pretreated with ellagic acid or anti-LOX-1 monoclonal antibody.	Ellagic Acid	214-226	Rac family small GTPase 1	Homo sapiens	69-73	
20692795-7	2010	We also found that oxLDL activated the membrane assembly of p47phox, Rac1, gp91 and p22phox, and the subsequent induction of ROS generation; however, ROS generation was markedly suppressed in cells pretreated with ellagic acid or anti-LOX-1 monoclonal antibody.	Ellagic Acid	214-226	cytochrome b-245 alpha chain	Homo sapiens	84-91	
20692795-7	2010	We also found that oxLDL activated the membrane assembly of p47phox, Rac1, gp91 and p22phox, and the subsequent induction of ROS generation; however, ROS generation was markedly suppressed in cells pretreated with ellagic acid or anti-LOX-1 monoclonal antibody.	Ellagic Acid	214-226	oxidized low density lipoprotein receptor 1	Homo sapiens	235-240	
20692795-11	2010	CONCLUSION: Findings from this study may provide insight into a possible molecular mechanism by which ellagic acid inhibits LOX-1-induced endothelial dysfunction.	Ellagic Acid	102-114	oxidized low density lipoprotein receptor 1	Homo sapiens	124-129	
20692795-12	2010	Our data indicate that ellagic acid exerts its protective effects by inhibiting NADPH oxidase-induced overproduction of superoxide, suppressing the release of NO by down-regulating iNOS, enhancing cellular antioxidant defenses, and attenuating oxLDL-induced LOX-1 up-regulation and eNOS down-regulation.	Ellagic Acid	23-35	nitric oxide synthase 2	Homo sapiens	181-185	
20692795-12	2010	Our data indicate that ellagic acid exerts its protective effects by inhibiting NADPH oxidase-induced overproduction of superoxide, suppressing the release of NO by down-regulating iNOS, enhancing cellular antioxidant defenses, and attenuating oxLDL-induced LOX-1 up-regulation and eNOS down-regulation.	Ellagic Acid	23-35	oxidized low density lipoprotein receptor 1	Homo sapiens	258-263