PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20467834-3 2010 The opioid agonist methadone has previously been demonstrated to inhibit hERG currents, and there are reports of serious cardiac arrhythmias and deaths from TdP and ventricular fibrillation in patients taking methadone. Methadone 19-28 ETS transcription factor ERG Homo sapiens 73-77 20467834-3 2010 The opioid agonist methadone has previously been demonstrated to inhibit hERG currents, and there are reports of serious cardiac arrhythmias and deaths from TdP and ventricular fibrillation in patients taking methadone. Methadone 209-218 ETS transcription factor ERG Homo sapiens 73-77 20467834-4 2010 The aim of the present study was to compare the effects of the opioid agonists methadone and heroin (3,6-diacetylmorphine) on hERG currents stably expressed in human embryonic kidney (HEK 293) cells using the whole-cell configuration of the patch-clamp technique. Methadone 79-88 ETS transcription factor ERG Homo sapiens 126-130 20467834-5 2010 Both methadone and heroin inhibit hERG currents in a concentration-dependent manner. Methadone 5-14 ETS transcription factor ERG Homo sapiens 34-38 20467834-7 2010 In conclusion, the potency for block of hERG currents is about 100-fold lower for heroin when compared to methadone. Methadone 106-115 ETS transcription factor ERG Homo sapiens 40-44