PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20185792-0 2010 Acadesine inhibits tissue factor induction and thrombus formation by activating the phosphoinositide 3-kinase/Akt signaling pathway. acadesine 0-9 AKT serine/threonine kinase 1 Homo sapiens 110-113 20185792-6 2010 In endothelial cells and macrophages, acadesine activated the phosphoinositide 3-kinase/Akt signaling pathway, reduced the activity of mitogen-activated protein kinases, and consequently suppressed TF expression by inhibiting the activator protein-1 and NF-kappaB pathways. acadesine 38-47 AKT serine/threonine kinase 1 Homo sapiens 88-91 20185792-8 2010 CONCLUSION: Acadesine inhibits TF expression and thrombus formation by activating the phosphoinositide 3-kinase/Akt pathway. acadesine 12-21 AKT serine/threonine kinase 1 Homo sapiens 112-115