PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20165829-1	2010	AIMS/HYPOTHESIS: Glucosamine, generated during hyperglycaemia, causes insulin resistance in different cells.	Glucosamine	17-28	insulin	Homo sapiens	70-77	
20165829-2	2010	Here we sought to evaluate the possible role of endoplasmic reticulum (ER) stress in the induction of insulin resistance by glucosamine in skeletal muscle cells.	Glucosamine	124-135	insulin	Homo sapiens	102-109	
20165829-5	2010	In addition, glucosamine impaired insulin-stimulated 2-DG uptake in both rat and human myotubes.	Glucosamine	13-24	insulin	Homo sapiens	34-41	
20165829-6	2010	Interestingly, pretreatment of both rat and human myotubes with the chemical chaperones 4-phenylbutyric acid (PBA) or tauroursodeoxycholic acid (TUDCA), completely prevented the effect of glucosamine on both ER stress induction and insulin-induced glucose uptake.	Glucosamine	188-199	insulin	Homo sapiens	232-239	
20165829-10	2010	CONCLUSIONS/INTERPRETATION: In this work we show that glucosamine-induced ER stress causes insulin resistance in both human and rat myotubes and impairs GLUT4 production and insulin-induced glucose uptake via an ATF6-dependent decrease of the GLUT4 regulators MEF2A and PGC1alpha.	Glucosamine	54-65	insulin	Homo sapiens	91-98	
20165829-10	2010	CONCLUSIONS/INTERPRETATION: In this work we show that glucosamine-induced ER stress causes insulin resistance in both human and rat myotubes and impairs GLUT4 production and insulin-induced glucose uptake via an ATF6-dependent decrease of the GLUT4 regulators MEF2A and PGC1alpha.	Glucosamine	54-65	insulin	Homo sapiens	174-181