PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20160148-2 2010 In the year 2000, TSC2 gene mutations were found in LAM cells; in 2001 the tuberous sclerosis complex (TSC) genes were discovered to regulate cell size in Drosophila via the kinase TOR (target of rapamycin); and in 2008 the results were published of a clinical trial of rapamycin, a specific inhibitor of TOR, in patients with TSC and LAM with renal angiomyolipomas. Sirolimus 196-205 Target of rapamycin Drosophila melanogaster 181-184