PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20132660-5 2010 We have shown that nilotinib induces apoptosis in imatinib-resistant K562 CML cells which have the wild-type BCR-ABL fusion gene almost to the same extent as it does in the parental sensitive cells by the increase in caspase-3 enzyme activity and the decrease in mitochondrial membrane potential. Imatinib Mesylate 50-58 caspase 3 Homo sapiens 217-226