PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20067833-0 2010 High glucose induces suppression of insulin signalling and apoptosis via upregulation of endogenous IL-1beta and suppressor of cytokine signalling-1 in mouse pancreatic beta cells. Glucose 5-12 interleukin 1 beta Mus musculus 100-108 20067833-4 2010 The aim of this study was to investigate whether high glucose can influence endogenous interleukin-1beta (IL-1beta) and SOCS expression thus affecting insulin signalling and survival in insulin-producing mouse pancreatic beta cells (betaTC-6). Glucose 54-61 interleukin 1 beta Mus musculus 87-104 20067833-4 2010 The aim of this study was to investigate whether high glucose can influence endogenous interleukin-1beta (IL-1beta) and SOCS expression thus affecting insulin signalling and survival in insulin-producing mouse pancreatic beta cells (betaTC-6). Glucose 54-61 interleukin 1 beta Mus musculus 106-114 20067833-7 2010 Glucose-induced attenuation of IRS-2/Akt-mediated signalling was associated with increased IL-1beta expression. Glucose 0-7 interleukin 1 beta Mus musculus 91-99 20067833-11 2010 These results indicated that glucose-induced endogenous IL-1beta expression increased betaTC-6 cells apoptosis by inhibiting, at least in part, IRS-2/Akt-mediated signalling through SOCS-1 upregulation. Glucose 29-36 interleukin 1 beta Mus musculus 56-64