PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19932868-0 2009 Taurine-deficient diet up-regulated cystathionine beta-synthase monoallele in hemizygous cystathionine beta-synthase knockout mice. Taurine 0-7 cystathionine beta-synthase Mus musculus 36-63 19932868-0 2009 Taurine-deficient diet up-regulated cystathionine beta-synthase monoallele in hemizygous cystathionine beta-synthase knockout mice. Taurine 0-7 cystathionine beta-synthase Mus musculus 89-116 19932868-2 2009 Reduced CBS activity could decrease cysteine and taurine biosyntheses (metabolites of homocysteine degradation) and lead to less taurocholic acid production with a resultant increased cholesterol content. Taurine 49-56 cystathionine beta-synthase Mus musculus 8-11 19932868-3 2009 We hypothesized that a deficiency in CBS genetic material and enzyme activity would reduce taurine synthesis, which would lead to an elevated cholesterol concentration. Taurine 91-98 cystathionine beta-synthase Mus musculus 37-40 19932868-9 2009 Three important findings were a differential sex response of CBS mRNA to feeding the vitamin B(6) diet; CBS (+/-) mice had a significantly lower plasma cholesterol concentration, contrary to what was anticipated; and during feeding, the taurine- and cysteine-deficient diet, CBS mRNA levels in CBS (+/-) mice were reduced only 13% rather than the expected 50%. Taurine 237-244 cystathionine beta-synthase Mus musculus 104-107 19932868-9 2009 Three important findings were a differential sex response of CBS mRNA to feeding the vitamin B(6) diet; CBS (+/-) mice had a significantly lower plasma cholesterol concentration, contrary to what was anticipated; and during feeding, the taurine- and cysteine-deficient diet, CBS mRNA levels in CBS (+/-) mice were reduced only 13% rather than the expected 50%. Taurine 237-244 cystathionine beta-synthase Mus musculus 104-107 19932868-9 2009 Three important findings were a differential sex response of CBS mRNA to feeding the vitamin B(6) diet; CBS (+/-) mice had a significantly lower plasma cholesterol concentration, contrary to what was anticipated; and during feeding, the taurine- and cysteine-deficient diet, CBS mRNA levels in CBS (+/-) mice were reduced only 13% rather than the expected 50%. Taurine 237-244 cystathionine beta-synthase Mus musculus 104-107 19932868-10 2009 We conclude that the remaining CBS monoallele is up-regulated in mice when fed a taurine-deficient diet to produce additional CBS mRNA. Taurine 81-88 cystathionine beta-synthase Mus musculus 31-34 19932868-10 2009 We conclude that the remaining CBS monoallele is up-regulated in mice when fed a taurine-deficient diet to produce additional CBS mRNA. Taurine 81-88 cystathionine beta-synthase Mus musculus 126-129