PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19931478-9 2010 We have shown that HIV-1 protease drugs such as tipranavir, nelfinavir, lopinavir, and atazanavir differ in their binding modes on each other for metabolic clearance in CYP3A4, whereas ritonavir, amprenavir, indinavir, saquinavir, fosamprenavir, and darunavir share the same binding mode. Darunavir 250-259 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 169-175