PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1991962-3 1991 Over a wide range of concentrations (10(-5) to 10(-8) M), DXS inhibited the production of MCAF at the mRNA and protein level in a human fibrosarcoma cell line, which was stimulated with either IL-1 or TNF-alpha. Dexamethasone 58-61 C-C motif chemokine ligand 2 Homo sapiens 90-94 1991962-3 1991 Over a wide range of concentrations (10(-5) to 10(-8) M), DXS inhibited the production of MCAF at the mRNA and protein level in a human fibrosarcoma cell line, which was stimulated with either IL-1 or TNF-alpha. Dexamethasone 58-61 tumor necrosis factor Homo sapiens 201-210 1991962-6 1991 In addition, a nuclear run-off analysis revealed that DXS also inhibited the transcription of IL-1- or TNF-activated MCAF genes. Dexamethasone 54-57 tumor necrosis factor Homo sapiens 103-106 1991962-6 1991 In addition, a nuclear run-off analysis revealed that DXS also inhibited the transcription of IL-1- or TNF-activated MCAF genes. Dexamethasone 54-57 C-C motif chemokine ligand 2 Homo sapiens 117-121 1991962-7 1991 Therefore, both the destabilization of MCAF mRNA and the inhibition of transcription of the gene contribute to the decrease in the MCAF mRNA steady state level by DXS. Dexamethasone 163-166 C-C motif chemokine ligand 2 Homo sapiens 39-43 1991962-7 1991 Therefore, both the destabilization of MCAF mRNA and the inhibition of transcription of the gene contribute to the decrease in the MCAF mRNA steady state level by DXS. Dexamethasone 163-166 C-C motif chemokine ligand 2 Homo sapiens 131-135