PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1987304-4 1991 Soluble mediators such as thrombin or histamine cause endothelial cell activation via a signal transduction mechanism that hydrolyzes phosphatidylinositol 4,5-bisphosphate (IP), liberating inositol trisphosphate (IP3). Phosphatidylinositol 4,5-Diphosphate 134-171 coagulation factor II, thrombin Homo sapiens 26-34